Large vessel occlusion refers to the blockage of major arteries supplying blood to the brain, such as the internal carotid artery or middle cerebral artery. This condition is a leading cause of acute ischemic stroke, a medical emergency that requires immediate intervention to restore blood flow and prevent significant brain damage. Treatment typically involves mechanical thrombectomy, a procedure where a catheter is inserted into the affected artery to remove the clot and restore blood flow. Research in this area focuses on improving the detection, treatment, and outcomes of large vessel occlusions to reduce disability and mortality in stroke patients.